Review study on lactoferrin: A multifunctional protein
نویسندگان
چکیده
Lactoferrin is a glycoprotein of 703 amino acids originally isolated from milk. Lactoferrin exists in body fluids and can be found in the form of free iron, monoferric and diferic form. Scientist also found lactoferrin in the secretions of mammal’s pancreas, and in secondary neutrophil granules. Lactoferrin has wide range of functions which may range from binding of Lactoferrin with iron, in control of the availability of an enhanced immune system and as a strong bacteriostatic agent, but the exact mechanism of lactoferrin is still not clear.
منابع مشابه
جداسازی و خالص سازی لاکتوفرین از شیر گاو
Background and purpose: Lactoferrin is a multifunctional protein, which is useful for clinical and commercial applications. Recently it has been shown that ingestion of Lactoferrin has advantages including: immune system modulation, anti-microbial activity and antioxidant in neonates and adults in both animals and humans. The present study has been conducted with the purpose of isolation and op...
متن کاملAntimicrobial properties of lactoferrin.
Milk is a vital nutritional source for the offspring of all mammals, including humans. In addition to its nutritional value, it is a rich source of proteins including lactoferrin. Lactoferrin is a truly multifunctional protein that has been studied extensively over the past decades. It is best known for its ability to bind iron, which eventually led to the discovery of its antibacterial activit...
متن کامل[Lactoferrin - a glycoprotein of great therapeutic potentials].
Lactoferrin is an iron-binding glycoprotein, which is present in most biological fluids with particularly high levels in colostrum and in mammalian milk. Bovine lactoferrin is more than 70% homologous with human lactoferrin. Most of the clinical trials have used bovine lactoferrin for supplementation. This review summarizes the recent advances in explaining the mechanisms, which are responsible...
متن کاملStudying Lactoferrin N-Glycosylation
Lactoferrin is a multifunctional glycoprotein found in the milk of most mammals. In addition to its well-known role of binding iron, lactoferrin carries many important biological functions, including the promotion of cell proliferation and differentiation, and as an anti-bacterial, anti-viral, and anti-parasitic protein. These functions differ among lactoferrin homologs in mammals. Although con...
متن کاملMultifunctional iron bound lactoferrin and nanomedicinal approaches to enhance its bioactive functions.
Lactoferrin (Lf), an iron-binding protein from the transferrin family has been reported to have numerous functions. Even though Lf was first isolated from milk, it is also found in most exocrine secretions and in the secondary granules of neutrophils. Antimicrobial and anti-inflammatory activity reports on lactoferrin identified its significance in host defense against infection and extreme inf...
متن کامل